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Phase separation in biology

less than 1 minute read

Published:

Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, from via protein Read more

Discrete error and convergence

less than 1 minute read

Published:

I was asked a question today about a typical way to present the error between a numerical scheme and an exact solution, and the convergence of the method. I will demonstrate one method that is typically used based on the $L_{2}$-norm of the norm. Read more

The Art of Action or Work

2 minute read

Published:

In this world outside all living beings constantly working. Everybody’s ambition is to excel, but despite all honest efforts, some achieve, many never achieve. The temptation of average human being is to condemn someone to his failure. Read more

conferences

portfolio

publications

Multi-Domain Interplay Controls Full-Length TDP-43 Phase Separation and Condensate Dynamics

Published in bioRxiv (preprint), 2026

Explicit-solvent, near-atomic resolution coarse-grained simulations reveal how the interplay among TDP-43 domains drives phase separation of the full-length protein, capturing the role of the conserved LCD helix, aromatic and N-terminal residues, phosphomimicking mutations, and NTD-NTD dimer formation in condensate dynamics. Read more

Recommended citation: Ping, X., Badr, R. G. M., Hutten, S., Chen, X., Baltz, L., Yadav, M., Hoeppner, J. S., Schmid, F., Dormann, D., & Stelzl, L. S. (2026). "Multi-Domain Interplay Controls Full-Length TDP-43 Phase Separation and Condensate Dynamics." bioRxiv. https://doi.org/10.64898/2026.06.03.729912 https://www.biorxiv.org/content/10.64898/2026.06.03.729912v1

research

talks

One less parameter least-square fitting

Published:

This is a description of your talk, which is a markdown files that can be all markdown-ified like any other post. Yay markdown! https://www.physik.uni-leipzig.de/~janke/CompPhys19/ Read more

teaching

Statistical Physics & Thermodynamics (Mentor)

Graduate course, Freie Universität Berlin, Institute of Physics, 2022

Mentored graduate students through the foundations of thermodynamics and statistical mechanics, connecting microscopic models to macroscopic thermodynamic behaviour. Read more

Quantum Mechanics (Tutor)

Under-Graduate course, Johannes Gutenberg Universität, Institute of Physics, 2023

Led weekly tutorial sessions accompanying the undergraduate quantum mechanics course, guiding students through problem sets and the core concepts of the lectures. Read more

Advanced Statistical Physics (Tutor)

Graduate course, Johannes Gutenberg Universität, Institute of Physics, 2023

Tutor for the graduate Advanced Statistical Physics course, leading problem-solving sessions that extended the lecture material toward interacting systems and collective behaviour. Read more

Tutorial Coarse-Graining

Programming, Best western hotel, Nierstein, 2023

A hands-on programming tutorial at the IRTG school introducing coarse-grained molecular modelling — how to build reduced-resolution models, run simulations, and analyse the resulting trajectories. Read more

Advanced Statistical Physics (Tutor)

Graduate course, Johannes Gutenberg Universität, Institute of Physics, 2024

Tutor for the graduate Advanced Statistical Physics course (2024/25 iteration), guiding students through weekly problem sets and the concepts underpinning the lectures. Read more